The Renin-Angiotensin-Aldosterone System in Health and Cardiovascular Disease
Sealey JE, Bühler FR, Laragh JH, Vaughan Jr. ED: The physiology of renin secretion in essential hypertension: Estimation of renin secretion rate and renal plasma flow from peripheral and renal vein renin levels. Am. J. Med. 55:391-401, 1973.
Sealey JE, Laragh JH: A proposed cybernetic system for sodium and potassium homeostasis: Coordination of aldosterone and intrarenal physical factors. Kidney Intl., 6:281-290, 1974.
Sealey JE, Atlas SA, Laragh JH: Linking the kallikrein and renin systems via activation of inactive renin. New data and a hypothesis. Am. J. Med. 65:994-1000, 1978.
Morganti A, Lopez-Ovejero JA, Pickering TG, Laragh JH: Role of the sympathetic nervous system in mediating the renin response to head up tilt. Their possible synergism in defending blood pressure against postural changes during sodium deprivation. Amer. J. Cardiol. 43: 600-604, 1979.
Morganti A, Pickering TG, Lopez-Ovejero JA, Laragh JH: Endocrine and cardiovascular influences of converting enzyme inhibition with SQ14225 in hypertensive patients in the supine position and during head-up tilt before and after sodium depletion. J. Clin. Endocrinol. Metab. 50: 748-754, 1980.
Sealey JE, Blumenfeld JD, Bell GM, Pecker MS, Sommers SC, Laragh JH: On the renal basis for essential hypertension: Nephron heterogeneity with discordant renin secretion and sodium excretion causing a hypertensive vasoconstriction-volume relationship. J. Hypertens. 6:763-777, 1988.
Resnick LM, Laragh JH, Sealey JE, Alderman MH: Divalent cations in essential hypertension. Relations between serum ionized calcium, magnesium, and plasma renin activity. N. Engl. J. Med. 309:888-891, 1983.
Sealey JE, Trenkwalder P, Gahnem F, Catanzaro DF, Laragh JH: Plasma renin methodology: inadequate sensitivity and accuracy of direct renin assay for clinical applications compared with the traditional enzymatic PRA assay. J. Hypertens. 13: 27-30,1995.
Trenkwalder P, James GD, Laragh JH, Sealey JE: Plasma renin activity and plasma prorenin are not suppressed in hypertensives surviving to old age. Am. J. Hypertens. 9: 621-627, 1996.
Blumenfeld JD, Sealey JE, Mann SA, Bragat A, Marion R, Pecker MS, Sotelo J, August PA, Pickering TG, Laragh JH: Beta-adrenergic blockade as a therapeutic approach for suppressing the renin-angiotensin-aldosterone system in normotensives and hypertensives. Am. J. Hypertens 12:451-459, 1999.
Devereux RB, Case DB, Alderman MH, Pickering TG, Chien, Laragh JH: Possible role of increased blood viscosity in the hemodynamics of systemic hypertension. Am. J. Cardiology 85: 1265-1268, 2000.
Alderman MH, Cohen HW, Sealey JE, Laragh JH: Plasma renin activity levels in hypertensive persons: their wide range and lack of suppression in diabetic and in most elderly patients. Am. J. Hypertension 17:1-7, 2004.
Gonzalez MC, Cohen HW, Sealey JE, Laragh JH. Enduring direct association of baseline plasma renin activity with all-cause and cardiovascular mortality in hypertensive patients. Am J Hypertens 2011; 24:1181-1186
Sim JJ, Bhandari SK, Shi J, Kalantar-Zadeh K, Rasgon SA, Sealey JE, Laragh JH. Plasma renin activity (PRA) levels and antihypertensive drug use in a large healthcare system. Am J Hypertens 2011;25:379-388.
Sealey JE, Bühler FR, Laragh JH, Vaughan Jr. ED: The physiology of renin secretion in essential hypertension: Estimation of renin secretion rate and renal plasma flow from peripheral and renal vein renin levels. Am. J. Med. 55:391-401, 1973.
Sealey JE, Laragh JH: A proposed cybernetic system for sodium and potassium homeostasis: Coordination of aldosterone and intrarenal physical factors. Kidney Intl., 6:281-290, 1974.
Sealey JE, Atlas SA, Laragh JH: Linking the kallikrein and renin systems via activation of inactive renin. New data and a hypothesis. Am. J. Med. 65:994-1000, 1978.
Morganti A, Lopez-Ovejero JA, Pickering TG, Laragh JH: Role of the sympathetic nervous system in mediating the renin response to head up tilt. Their possible synergism in defending blood pressure against postural changes during sodium deprivation. Amer. J. Cardiol. 43: 600-604, 1979.
Morganti A, Pickering TG, Lopez-Ovejero JA, Laragh JH: Endocrine and cardiovascular influences of converting enzyme inhibition with SQ14225 in hypertensive patients in the supine position and during head-up tilt before and after sodium depletion. J. Clin. Endocrinol. Metab. 50: 748-754, 1980.
Sealey JE, Blumenfeld JD, Bell GM, Pecker MS, Sommers SC, Laragh JH: On the renal basis for essential hypertension: Nephron heterogeneity with discordant renin secretion and sodium excretion causing a hypertensive vasoconstriction-volume relationship. J. Hypertens. 6:763-777, 1988.
Resnick LM, Laragh JH, Sealey JE, Alderman MH: Divalent cations in essential hypertension. Relations between serum ionized calcium, magnesium, and plasma renin activity. N. Engl. J. Med. 309:888-891, 1983.
Sealey JE, Trenkwalder P, Gahnem F, Catanzaro DF, Laragh JH: Plasma renin methodology: inadequate sensitivity and accuracy of direct renin assay for clinical applications compared with the traditional enzymatic PRA assay. J. Hypertens. 13: 27-30,1995.
Trenkwalder P, James GD, Laragh JH, Sealey JE: Plasma renin activity and plasma prorenin are not suppressed in hypertensives surviving to old age. Am. J. Hypertens. 9: 621-627, 1996.
Blumenfeld JD, Sealey JE, Mann SA, Bragat A, Marion R, Pecker MS, Sotelo J, August PA, Pickering TG, Laragh JH: Beta-adrenergic blockade as a therapeutic approach for suppressing the renin-angiotensin-aldosterone system in normotensives and hypertensives. Am. J. Hypertens 12:451-459, 1999.
Devereux RB, Case DB, Alderman MH, Pickering TG, Chien, Laragh JH: Possible role of increased blood viscosity in the hemodynamics of systemic hypertension. Am. J. Cardiology 85: 1265-1268, 2000.
Alderman MH, Cohen HW, Sealey JE, Laragh JH: Plasma renin activity levels in hypertensive persons: their wide range and lack of suppression in diabetic and in most elderly patients. Am. J. Hypertension 17:1-7, 2004.
Gonzalez MC, Cohen HW, Sealey JE, Laragh JH. Enduring direct association of baseline plasma renin activity with all-cause and cardiovascular mortality in hypertensive patients. Am J Hypertens 2011; 24:1181-1186
Sim JJ, Bhandari SK, Shi J, Kalantar-Zadeh K, Rasgon SA, Sealey JE, Laragh JH. Plasma renin activity (PRA) levels and antihypertensive drug use in a large healthcare system. Am J Hypertens 2011;25:379-388.
